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Francis Y. Lee, M.D.
 •  Special Honors
 •  Academic Assignments (Present & Past)
 •  Research
 •  Publications
 •  Presentations
 
   



PUBLICATIONS:

  1. Kim YM, Lee SH, Lee FY, Koo KH and Cho KH: Morphologic and biomechanical study of avascular necrosis of the femoral head. Orthopaedics 14:1111-1116, 1991.
  2. Seong SC, Matsumura T, Lee FY, Whelan MC, Li XQ and Trippel SB: Insulin-like growth factor I regulation of Swarm rat chondrosarcoma chondrocytes in culture. Experimental Cell Research 211:238-244, 1994.
  3. Harten RD, Lee FY, Hurowitz EJ, Arakal RJ, Zimmerman MC, and Behrens FF: Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing. Journal of Orthopaedic Research, 15(4):570-576, 1997.
  4. Lee FY*, Hazan EJ, Kloen P, Mankin HJ.  Reconstruction of shoulder joint using osteoarticular acetabular allograft after scapular resection.  A report of two cases.  Clinical Orthopaedics and Related Research, 357: 116-121, 1998.
  5. Benevenia J, Lee FY, Buechel FF, Parsons JR: Aggressive Granulomatous Lesion following Total Knee Replacement Arthroplasty. Journal of Biomedical Materials Research Applied Biomaterials, 43(4):473-477, 1998.
  6. Lee FY*, Gebhardt MC, Keel SB, Rosenthal DI.  Orthopaedic-Pathology-Radiology Conference.  A discrete soft tissue mass in the distal thigh of 29-year–old male.  Clinical Orthopaedics and Related Research, 357: 247-250, 1998.
  7. Lee FY*, Behrens FF, DeFouw DO, and Einhorn TA: Programmed Removal of Chondrocytes During Enchondral Fracture Healing. Journal of Orthopaedic Research, 16(1), 144-149, 1998.
  8. Lee FY*, Rho JY, Harten R, Parsons JR, Behrens FF.  Micromechanical Properties of Primary Spongiosa and Epiphyseal Trabecular Bone.  Journal of Pediatric Orthopaedics, 18: 582-585, 1998.
  9. Lee FY*, Montgomery M, Hazan EJ, Keel SB, Mankin HJ, Kattapuram S.  Recurrent giant cell tumor presenting as an isolated soft Tissue mass.  A report of four cases.  Journal of Bone and Joint Surgery (Am), 81A: 703-707, 1999.
  10. Lee FY*, Mankin HJ, Gebhardt MC, Springfield D, Fondren G, Jennings LC, Rosenberg A.  Outcome analysis of chondrosarcoma. Journal of Bone and Joint Surgery (Am) 81A: 326-338, 1999.
  11. Margau R, Babyn P, Cole W, Smith C, Lee F: MR imaging of simple bone cysts in children: not so simple. Pediatric Radiology, 30:551-557, 2000.
  12. Ramappa AJ, Lee FY, Tang P, Carlson JR, Gebhardt MC, Mankin HJ: Chondroblastoma of bone. Journal of bone and Joint Surgery, 82A:1140-1145, 2000.
  13. Lee FY*, Hazan EJ, Gebhardt MC, Mankin HJ.  An experimental model for allograft fracture repair.  Journal of Orthopaedic Research, 18:303-306, 2000.
  14. Patari S, Lee FY*, Behrens FF: Coronal split fracture in a partially fused physis in the proximal tibia. Journal of Pediatric Orthopaedics 21:451-455, 2001.
  15. Lee FY*, Keel SB, Gebhardt MC, Rosenthal DI: Intra-articular lipoma with osteochondral metaplasia in the knee joint. Skeletal Radiology, 30:230-233, 2001.
  16. Ahmad CS, Lee FY*: An all arthroscopic soft tissue balancing technique for lateral patellar instability. Arthroscopy, 17:555-557, 2001.
  17. Osgood G, Lee FY*, Parisien MV, Ruzal-Shapiro C: Magnetic resonance imaging depiction of tight iliotibial band in melorheostosis associated with severe external rotation deformity, limb shortening and patellar dislocation in planning surgical correction. 2002; Skeletal Radiology, 31:49-52.
  18. Lee FY*, Zawadsky M, Parisien M, Ho M, M VVVS, Jayaraman T, Dick HM: A novel translocation t(9;12)(q22;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis. Cancer Genetics and Cytogenetics. 2002; 132(1)68-70.
  19. Lee FY*, Storer SK, Hazan EJ, Gebhardt MC, Mankin HJ: Repair of bone allograft fracture using bone morphogenetic protein-2 in an animal experimental model. Clinical Orthopaedics and Related Research, April, 397:119-126, 2002.
  20. Lee FY*, Chapman C: In Situ Pinning of the Hip for Stable Slipped Capital Femoral Epiphysis on a Radiolucent Table: Modification of Percutaneous Pinning Technique Using a Fracture Table. Journal of Pediatric Orthopaedics, 23(1): 27-29, 2003
  21. MG Vitale, JC Choe, MW Hwang, RM Bauer, JE Hyman, FY Lee, DP Roye: Postoperative Use of Ketorolac Tromethamine in Children Undergoing Scoliosis Surgery. The Spine Journal, 2003; 3:55-62.
  22. Ugwanali O, Vitale MG, Hyman JE, Lee FY, Roye DP: Effect of bracing on the quality of adolescent with idiopathic scoliosis. The Spine Journal, March, 4:254-260, 2004.
  23. Lee FY*, Hornicek FJ, Dick HM, Mankin HJ: Synovial chondromatosis of the foot. Clinical Orthopaedic and Related Research, April, 423:186-190, 2004.
  24. Roposch A, Bhaskar AR, Lee F, Adedapo S, Mousny M, Alman BA:  Orthopaedic manifestations of Brachmann-de Lange syndrome: a report of 34 patients. Journal of Pediatric Orthopaedics, 2004;13 (B):118-122.
  25. Lee FY*, Yu John, Parisien MV, Chang SS, Fawaaz R: Diagnostic accuracy and limitations of positron emission tomography for the diagnosis of cartilaginous tumors. Journal of Bone and Joint Surgery, 2004 Dec;86-A(12):2677-85. 2004.
  26. Chang SS, Suratwala S, Jung KM, Doppelt J, Zhang HJ, Blaine TA, Kim TW, Winchester RJ, Lee FY*: Bisphosphonate may reduce recurrence in GCT by inducing apoptosis. Clinical Orthopaedics and Related Research, September, 426:103-109, 2004.
  27. Delloye C, Suratwala S, Valentin-Opran A, Cornu O, Lee FY: Treatment of Allograft Nonunions with Recombinant Human Bone Morphogenetic Proteins (rhBMP): Early Clinical Results. Acta Orthopaedica Belgica, 2004 70:591-597.
  28. Lee FY*, Scoeb JS, Yu J, Dick HM: Operative lengthening of the humerus: Indications, benefits and complications. Journal of Pediatric Orthopaedics, September, 2005, 25: 613-616.
  29. Yoon AJ, Marisien M, Feldman F, Lee FY: Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal simus mucosa: Case report and review of the literature. Skeletal Radiology, 2005 Oct;34(10):653-7.
  30. Vitale MG, Choe JC, Vitale MA, Lee FY, Hyman JE, Roye DP Jr: Patient-based outcomes following clubfoot surgery: a 16-year follow-up study. Journal of Pediatric Orthopaedics. 2005 Jul-Aug;25(4):533-8.
  31. Storer SK, Vitale MG, Hyman JE, Lee FY, Choe JC, Roye DP Jr: Correction of adolescent idiopathic scoliosis using thoracic pedicle screw fixation versus hook constructs. Journal of Pediatric Orthopaedics. 2005 Jul-Aug;25(4):415-9.
  32. Liao T, Yurgelun M, Chang SS, Murakami K, Zhang HZ, Parisien MV, Blaine TA, Kim W, Winchester RJ, Lee FY*: Recruitment of osteoclast precursors by stromal cell derived factor-1 in giant cell tumor of bone. Journal of Orthopaedic Research, 2005 Jan;23(1):203-9.
  33. Blaine TA, Kim YS, Voloshin I, Chen D, Murakami K, Chang SS, Winchester R, Lee FY, O'keefe RJ, Bigliani LU: The molecular pathophysiology of subacromial bursitis in rotator cuff disease. J Shoulder Elbow Surg. 2005 Jan-Feb;14(1 Suppl S):84S-89S.
  34. Vitale MG, Roye EA, Choe JC, Hyman JE, Lee FY, Roye DP Jr: Assessment of health status in patients with cerebral palsy: what is the role of quality-of-life measures? Journal of Pediatric OrthopaeDICS. 2005 Nov-Dec;25(6):792-7.
  35. Yu J, Chang SS, Suratwala S, Chung W, Abdelmessieh P, Lee HJ, Yang J, Lee FY*: Zoledronate induces apoptosis in stromal cells of unicameral bone cyst. Journal of Orthopaedic Research, 2005 May 24; 23(5):1004-12
  36. Lee FY*, Kim DW, Karmin JA, Hong D, Chang SS, Fujisawa M, Takayanagi H, Bigliani LU, Blaine TA, Lee HJ: mu -calpain regulates RANKL-supported osteoclastogenesis via NF-kappa B activation in raw 264.7 cells. Jouranl of Biological Chemistry. 2005 Jun 13; 280(33):29929-36.
  37. Vitale MA, Choe JC, Sesko AM, Hyman JE, Lee FY, Roye DP Jr, Vitale MG: The effect of limb length discrepancy on health-related quality of life: is the '2 cm rule' appropriate? Journal of Pediatric Orthopaedics B. 2006 Jan;15(1):1-5.
  38. Kim DW, Lee HJ, Karmin J, Lee SE, Chang SS, Tolchin B, Lin S, Cho SK, Kwon A, Ahn JM, and Lee FY*: Mechanical Loading Differentially Regulates Membrane-Bound and Soluble RANKL Availability in MC3T3-E1 Cells. Annals of New York Academy of Science, April 2006, Vol 1068, pp568-572.
  39. Kim YS, Bigliani LU, Fujisawa M, Murakami K, Chang SS, Lee HJ, Lee FY, Blaine TA: Stromal cell-derived factor 1 (SDF-1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti-inflammatory agents. Journal of Orthopaedic Research. 2006 Jun 15, 24: 1756-64.
  40. Lee FY*, Sinicropi S, Vitale MG, Lee FS, Roye DP, Choi IH: Treatment of congenital pseudarthrosis of tibia with recombinant human bone morphogenetic protein-7: A prospective study. Journal of Bone and Joint Surgery, 2006 Mar;88(3):627-33
  41. Lowenstein JE, Matsumoto H, Vitale MG, Weidenbaum M, Gomez JA, Lee FY, Hyman JE, Roye DP Jr: Coronal and sagittal plane correction in adolescent idiopathic scoliosis: A comparison between all pedicle screw versus hybrid thoracic hook lumbar screw constructs. Spine. 2007 Feb 15;32(4):448-52.
  42. Kim DW, Seo SW, Cho S, Chang SS, Lee HW, Lee SE, Block JA, Hei TK, Lee FY*: Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. Journal of Orthopaedic Research, March 7th 2007, 25(6):820-8.
  43. Minematsu H, Seo S, Adelmir A, Lee FY*: CALCINEURIN/NFATC1 AXIS REGULATES UHMWPE WEAR PARTICLE-INDUCED CYTOKINE EXPRESSION IN MACROPHAGES. The Annals of New York Academy of Science. 2007 Nov;1117:143-50.
  44. Seo SW, Adelmir A, Minematsu H, Lee FY*: ERK SIGNALING REGULATES M-CSF EXPRESSION INDUCED BY TITANIUM NANOPARTICLES IN MC3T3-E1 MURINE CALVARIAL PRE-OSTEOBLASTIC CELLS. The Annals of New York Academy of Science. 2007 Nov;1117:151-8.
  45. Celil Aydemir AB, Lee S, Won Kim D, Gardner TR, Prince D, Mok Ahn J,  Lee FY*: Calcineurin/NFATc axis mediated fluid shear stress-induced COX-2 expression in human mesenchymal cells. The Annals of New York Academy of Science. 2007, Nov;1117:138-42.
  46. Tuan RS, Lee FY, Konttinen YT, Wilkinson JM, Smith RL: What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? Journal of American Academy of Orthopaedic Surgeons. 2008. 16(S):42-48.
  47. Sanjeev Suratwala, Samuel K. Cho, Jonathan Van Rattle, Sang H Park, Sung W Seo, Seong-Sil chang, Thomas R. Gardner, Lee, FY*: Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite: An Experimental Study. The Journal of Bone and Joint Surgery 2008. 90A (10):2189-2195.
  48. Seo SW, Cho SK, Storer SK, Lee FY. Zoledronate reduces unwanted bone resorption in intercalary bone allografts. Int Orthop. 2009 Apr 3.
  49. Seo SW, Lee D, Minematsu H, Kim AD, Shin M, Cho SK, Kim DW, Yang J, Lee FY. Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis. Bone. 2009 Nov 4. [Epub ahead of print] PubMed PMID: 19895919.
  50. Aydemir AB, Minematsu H, Gardner TR, Kim KO, Ahn JM, Lee FY. Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells. Bone. 2009 Sep 11. [E-PUB] PubMed PMID: 19748606.
  51. Cadet ER, Vorys GC, Rahman R, Park SH, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS. Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. Journal of Orthopaedic Research. 2009 Sep 9. PubMed PMID: 19743506
  52. Kim DW, Kim KO, Shin MJ, Ha JH, Seo SW, Yang J, Lee FY. siRNA-based targeting  of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells. Molecular Cancer. 2009 May 15;8:28.
  53. Mills J, Matos T, Charytonowicz E, Hricik T, Castillo-Martin M, Remotti F, Lee FY, Matushansky I. Characterization and comparison of the properties of sarcoma cell lines in vitro and in vivo. Human Cell. 2009 Nov;22(4):85-93. PubMed PMID: 19874397.
  54. Nho KC, Kim KO, Staples JR, Patel N, Minematsu, H, Nair K, Lee FY: Targeting Inflammatory Pathways in Osteosarcoma. Journal of Bone and Joint Surgery (Am), 2010 (In Press)

 

 

BOOKS AND CHAPTERS

  • Carol Morris, Lee FY and Gebhardt MC. Benign Bone Tumors, Chapter, OperativeOrthopaedic Surgery, Ed. Chapman M, Williams and Wilkins, 2000.
  • Lee FY and Lee HK. Basic science in musculoskeletal tumor, Chapter, Musculoskeletal Oncology, Ed. Lee HK, 1996, Korea.
  • Hyman J, Lee FY, Roye DP. Orthopaedic Surgery, Chapter, Pediatric Secrets, Ed, 200.
  • Seo SW, F Remotti, Lee FY: Chondrosarcoma, Orthopaedic Knowledge Update, Musculoskeletal Oncology.
  • Seo SW, Moon YL, Lee FY: Benign Cystic Lesions. Essentials of Orthopaedic Surgery, (In Preparation)
  • AAOS Comprehensive Orthopaedic Review. Section 1. Basic Science (2009) American Academy of Orthopaedic Surgeon
  • Self Assessment Examination, Basic Science. American Academy of Orthopaedic Surgeons