The Orthopaedic Research Society 2020 Annual Meeting

The Orthopaedic Research Society (ORS) 2020 Annual Meeting will include lectures and presentations from Columbia Orthopedics faculty as well as joint Orthopedics and Biomedical Engineering faculty member Clark T. Hung, PhD. ORS is an international hub for biologists, engineers, clinicians, surgeon-scientists, orthopaedic surgeons, and veterinarians within the field of musculoskeletal science and orthopaedic care. The meeting will take place on February 8 – 11 in Phoenix, Arizona and includes a grant writing course on, February 7, taught by Steve Thomopoulos, PhD, Director of the Carroll Laboratories for Orthopedic Surgery.

See below for the syllabus of presentations and lectures being presented by Columbia Orthopedics faculty and researchers:

Friday, February 7

Grant Writing:

• 8:00am - The Art of Grantsmanship Part II– Practical Skills. Stavros Thomopoulos, PhD. (Other course directors: Kurt Spindler, MD)

Saturday, February 8

Podium Session 4 - Shoulder – Clinical Studies:

• 8:30am - Paper No. 19 - Proteome Characterization of Tendon and Bursa in Rotator Cuff Disease. David Kovacevic. (Authors: Brittany P. Marshall; Rajesh Soni; Stavros Thomopoulos)

Spotlight Session 10 - Cellular and Molecular Mechanisms in Tendon Pathology:

• 11:55am - Paper No. 53 - Enhancing Tendon-to-Bone Attachment Healing Via Pharmacological Ikkβ Inhibition. Stavros Thomopoulos. (Authors: Mikhail Golman; Dimitrios Skouteris; Xiaoning Li)

Podium Session 7 - Pathological and Morphological Events in Osteoarthritis:

• 12:05pm - Paper No. 39 - Synoviocyte Mechanosensitivity is Modulated by Glucose Preconditioning in an In Vitro Model of Diabetic Osteoarthritis and Synovial Joint Insulin Resistance. (Authors: Neeraj Sakhrani; Lance A. Murphy; Andy J. Lee; Robert M. Stefani; Eric J. Semler; Roshan P. Shah; Christopher J. Visco; Xiaoning Yuan; Clark T. Hung)

ORS Spine Section Scientific Meeting:

• 12:30pm - Inflammatory Response of Rat Caudal Intervertebral Discs to Ex Vivo Dynamic Loading. Nadeen Chahine, PhD. (Other Authors: Hagar Kenawy; Samantha Marshall; Andy J. Lee; Quynhhoa Nguyen;  Clark T. Hung)

Podium Session 15 - Tendon –Biomaterials and Therapeutics:

• 3:35pm - Paper No. 81 - Primary Cilium and Hedgehog Signaling Synergistically Mediate Tendon Enthesis Mechanical Responses. Stavros Thomopoulos. (Other authors: Fei Fang)

Podium Session 19 - Shoulder –Computational and Technological Approaches:

• 4:50pm - Paper No. 102 - Python-Tooth-Inspired Device to Enhance Tendon-to-Bone Repair. Stavros Thomopoulos. (Other authors: Iden Kurtaliaj; Ethan Hoppe; Liana Tedesco; Eric Yoon; Lester Smith; David Kovacevic; Victor Birman; Guy Genin)

Sunday, February 9

Scientific Podium Session 22 - Arthritis Treatment and Therapy:

• 8:20am - Paper No. 117 - Ferrostatin-1 as an Inhibitor of Blood-induced Chondrocyte Cell Death. Clark T. Hung. (Other authors: Andy J. Lee; Lianna R. Gangi; Fereshteh Zandkarimi; Robert M. Stefani; Brent R. Stockwell)

Scientific Podium Session 23 - Intervertebral Disc:

• 8:50am – Paper No. 126 - In Vivo Deletion of HMGB1 Protects Against Inflammatory Induced Disc Degeneration. Nadeen Chahine (Authors: Kevin G. Burt; Adam Abraham)

Moderated Poster Presentation - Clinical Studies:

• 10:37am – Poster No. 518 - Orthopedic Surgeons Prescribe Fewer Opioids To Medicare Part D Patients In States With Medical Cannabis Laws. (Authors: Cesar D. Lopez; Venkat Boddapati; Charles J. Jobin; Thomas R. Hickernell)

Moderated Poster Presentation - Cartilage and Synovium:

• 10:49am - Poster No. 385 - Interleukin-1a Decreases Coefficient Of Friction Of Synovium Ex Vivo. (Authors: Lance A. Murphy; Lianna R. Gangi; Robert M. Stefani; Hagar M. Kenawy; Andy J. Lee; Gerard A. Ateshian; Roshan P. Shah; Clark T. Hung)

Moderated Poster Presentation - Tendon and Ligament:

• 11:01am - Poster No. 404 - Synovial Wrap For Supporting Primary Intra-articular Ligament Repair. (Authors: Lance A. Murphy; James Rogot; Neeraj Sakhrani; Robert Stefani; Andy Lee; Gerard Ateshian; Roshan Shah; Stavros Thomopoulos; Clark Hung)

Podium Session 35 - Tendon and Ligament–Healing and Regeneration:

• 4:30pm - Paper No. 206 - Intrasynovial Versus Extrasynovial Tendon Repair: An In Vivo Gene Expression and Histologic Study at the Early Phase of Healing. Stavros Thomopoulos. (Other authors: Susumu Yoneda; Hua Shen; Shelly E. Sakiyama-Elbert; Richard H. Gelberman)

Monday, February 10

Podium Session 52 - Tendon and Ligament – Mechanical and Biological Influences of Structure and Function:

• 5:10pm - Paper No. 297 - Toughening Mechanisms in Healthy and Pathologic Tendon Entheses. Stavros Thomopoulos. (Other authors: Mikhail Golman; Adam A. Abraham; Iden Kurtaliaj; Brittany P. Marshall; Yizhong Hu; X. Edward Guo; Guy Genin; Victor Birman)

Tuesday, February 11

Spotlight Session 62 - Disc Degeneration:

• 11:15am - Spotlight Speaker - Profiling Serum Cytokines in Patients with Disc Disease: Immune Dysregulation and Disease Biomarkers. Nadeen Chahine, PhD.

Posters 

Intervertebral Disc

• Poster No. 447 - TNFa Stimulation Reduces Glycosaminoglycan Content And Material Properties Of The Nucleus Pulposus. (Authors: Timothy Jacobsen; Nadeen O. Chahine)

Tendon and Ligament – Diseases and Disorders

• Poster No. 701 - Murine Rotator Cuff Disease Models: The Role Of Muscle Loading. (Authors: Adam C. Abraham; Fei Fang; Mikhail Golman; Panagiotis Oikonomou; Stavros Thomopoulos)

Tendon and Ligament – Treatment and Therapeutics

• Poster No. 756 - Rotator Cuff Enthesis Regeneration Via Engineered Delivery of Insulin- like Growth Factor-1 Mimics. (Authors: Anupama Prabhath; Varadraj Vernekar; Ellen Eisenberg; Mary Badon; Takayoshi Otsuka; Godwin Dzidotor; Jean- Emmanuel Avochinou; Sangamesh Kumbar; Nathaniel Dyment; Stavros Thomopoulos; Eckhard Weber; Cato Laurencin)

Intervertebral Disc – Injury and Healing

• Poster No. 996 - Inflammatory Response Of Rat Caudal Intervertebral Discs To Ex Vivo Dynamic Loading. (Authors: Hagar Kenawy; Samantha Marshall; Andy J. Lee; Quynhhoa Nguyen; Clark T. Hung; Nadeen O. Chahine)

Knee – Surgical and Non-Surgical Interventions

• Poster No. 1082 - Complication Rates And Length Of Stay In Computer-Assisted Vs. Conventional Total Knee Arthroplasty From 2010-2017: A NSQIP Database Study. (Authors: Anastasia Gazgalis; Jeremy S. Frederick; Thomas R. Hickernell; H. John Cooper; Roshan P. Shah; Jeffrey A. Geller; Alexander L. Neuwirth)
• Poster No. 1115 - Clinical And Functional Outcomes Of JourneyTM II Cr Total Knee System. Interim Results Of An Ongoing, Prospective, Multicenter Study. (Authors: Branko Kopjar; Pramod Achan; James MacDonald; Tad Gerlinger; Jimmy Chow; Michael Swank; Jeffrey Geller; Herbert Cooper; Pere Torner Pifarre; Jordi Villalba; Jonathan Miles; John Shields)

Hip – Surgical and Non-Surgical Interventions

• Poster No. 1163 - Decreasing Length Of Stay And Complication Rates In Robotic-Assisted THA In The NSQIP Database: An Analysis Of 2010-2017. (Authors: Jeremy S. Frederick; Anastasia Gazgalis; Thomas R. Hickernell; Jeffrey A. Geller; H. John Cooper; Roshan P. Shah; Alexander L. Neuwirth)
• Poster No. 1173 - Polyester Mesh Dressings Reduce Delayed Wound Healing After Total Hip Arthroplasty Compared To Silver-Impregnated Occlusive Dressings. (Authors: Carl L. Herndon; Josephine Coury; Nana O. Sarpong; Thomas R. Hickernell; Alexander L. Neuwirth; Jeffrey A. Geller; Roshan P. Shah; H. John Cooper)
• Poster No. 1190 - Lower Dosing Of Bupivacaine Spinal Anesthesia Is Not Associated With Improved Perioperative Outcomes Following Total Joint Arthroplasty. (Authors: Carl L. Herndon; Matthew Levitsky; Chimere Ezuma; Nana O. Sarpong; Thomas R. Hickernell; Alexander L. Neuwirth; Jeffrey A. Geller; Roshan P. Shah; H. John Cooper)
• Poster No. 2048 - Shorter-Duration Spinal Anesthesia Using Chloroprocaine Is Associated With Improved Perioperative Outcomes Following Total Joint Arthroplasty. (Authors: Carl L. Herndon; Roxana Martinez; Nana O. Sarpong; Thomas R. Hickernell; Alexander L. Neuwirth; Jeffrey A. Geller; Roshan P. Shah; H. John Cooper)
• Poster No. 2058 - Perioperative And Short-term Outcomes Of Primary Total Hip Arthroplasty Comparing The Direct Anterior Approach And Mini- Anterolateral Approach. (Authors: Carl L. Herndon; Nathan Drummond; Nana O. Sarpong; Thomas R. Hickernell; Alexander L. Neuwirth; Roshan P. Shah; H. John Cooper; Jeffrey A. Geller)
• Poster No. 2073 - Complication Rates And Length Of Stay In Computer-Assisted Vs. Conventional Total Hip Arthroplasty From 2010-2017: A NSQIP Database Study. (Authors: Jeremy S. Frederick; Anastasia Gazgalis; Thomas R. Hickernell; Jeffrey A. Geller; H. John Cooper; Roshan P. Shah; Alexander L. Neuwirth)

Clinical Studies – Omics and Biomarkers

• Poster No. 1386 - The Majority Of Postoperative Opioid Prescriptions Are From Non- Orthopedists: 12-Month Follow Up Of Total Joint Arthroplasty Patients. (Authors: Austin Kaidi; Akshay Lakra; Emma Jennings; Roshan P. Shah; Jeffrey A. Geller; Alexander L. Neuwirth; H. John Cooper; Thomas Hickernell)
• Poster No. 1387 - Chronic Opioid Users Consume Significantly More Opioids Than Opioid- Naive Patients: 12-Month Follow Up Of Total Joint Arthroplasty. (Authors: Patients Austin Kaidi; Akshay Lakra; Emma Jennings; Roshan P. Shah; Alexander Neuwirth; Jeffrey A. Geller; H. John Cooper; Thomas R. Hickernell)

Clinical Studies – Orthopaedic Quality and Value

• Poster No. 1404 - Intra-Operative Scrub Nurse Handoffs Increase Operative Times For Total Hip And Total Knee Arthroplasty. (Authors: Austin C. Kaidi; Bradley T. Hammoor; William N. Levine; Thomas R. Hickernell)
• Poster No. 2267 - Specific Intraoperative Events Cause Notable Increases In Airborne Particle Counts During Total Knee Arthroplasty. (Authors: Anastasia Gazgalis; Jeremy S. Frederick; Michael B. Held; Alexander L. Neuwirth; Nana O. Sarpong; Roshan P. Shah; Jeffrey A. Geller; H. John Cooper; Thomas R. Hickernell)
• Poster No. 2275 - Opioid Consumption Following Robotically Assisted Versus Conventional Total Knee Arthroplasty. (Authors: Austin C. Kaidi; Anastasia Gazgalis; Emma Jennings; Alexander L. Neuwirth; Roshan P. Shah; Jeffrey A. Geller; Thomas R. Hickernell)

Biomaterials

• Poster No. 1419 - Dual-Network Hydrogels With Complex Mechanical Properties For Nucleus Pulposus Replacement. (Authors: Samantha L. Marshall; Nadeen O. Chahine)

Cartilage and Synovium – Treatment and Therapeutics

• Poster No. 1520 - Graphite-containing Electroactive Fibers And Hydrogels For Cartilage Tissue Engineering. (Authors: Christopher Z. Mosher; Yilin Yang; Elisa C. Fang; Beini Wang; Clark T. Hung; Theanne N. Schiros; James C. Hone; Helen H. Lu)

Tendon and Ligament – Growth, Development and Aging

• Poster No. 1586 - Tgfbeta Signaling Is Necessary In Gli1-expressing Cells For Enthesis Development. (Authors: Lee Song; Mikhail Golman; Adam Abraham; Stavros Thomopoulos)

Tendon and Ligament – Injury and Healing

• Poster No. 1611 - SB-431542 Modulates The Wound Healing Response Of Ligament Fibroblasts: Implications Following ACL Reconstruction. (Authors: Andy J. Lee; Lance A. Murphy; Gerard A. Ateshian; Stavros A. Thomopoulos; Roshan P. Shah; Clark T. Hung)

Intervertebral Disc – Diseases and Disorders

• Poster No. 1857 - Mechanobiological Dysfunction Of Disease: Cell Stiffness Decreases With Severity Of Disc Degeneration And Inflammatory Stimulation. (Authors: Timothy Jacobsen; Hayley Jacobsen; Eric Leung; Venkat Boddapati; Christopher Filippi; Mitchell Levine; Ronald A. Lehman; Nadeen O. Chahine)

Intervertebral Disc – Treatment and Therapeutics

• Poster No. 1889 - Flexible 3D Printed Scaffolds And Cell-Seeded Alginate To Recapitulate The Complex Biomechanical Properties Of Intervertebral Disc. (Authors: Samantha L. Marshall; Timothy D. Jacobsen; Kevin Anton; Archana Murali; Nadeen O. Chahine)

Knee – Structure, Function and Mechanics

• Poster No. 1977 - Early Clinical And Patient-reported Results Of A Bi-cruciate Retaining Total Knee Implant: Six-month Results Of A Prospective Multicenter Study Of 149 Primary Tkas. (Authors: Branko Kopjar; Ran Schwarzkopf; James MacDonald; Tad Gerlinger; William Huang; Michael Swank; Thomas Huff; Mark Schinsky; Nirav Amin; Michael Ast; Michael Ries; Martin Roche; Jackson Jones; H. John Cooper)

Shoulder and Elbow – Growth, Development and Aging

• Poster No. 2078 - Early Osteoarthritis Observed After Recovery From Neonatal Brachial Plexus Palsy In A Mouse Model. (Authors: 
• Lynn Ann Forrester; Fei Fang;  Yizhong Hu; Benjamin D. Roye; X. Edward Guo; Stavros Thomopoulos)

Shoulder and Elbow – Surgical and Non-Surgical Interventions

• Poster No. 2115 - Biodegradable Subacromial Balloon Spacer For Irreparable Rotator Cuff Tears Reduces Superior Migration While Maintaining External Rotation Biomechanics. (Authors: Danica D. Vance; Dimitrios Skouteris; Linda A. Effiong; Silvio Torres Betanacur; Thomas R. Gardner; William N. Levine)

Late Breaking

• Poster No. 2322 - Impact Of Sex-based Differences On Cartilage Tissue Engineering With Canine Chondrocytes. (Authors: Lianna R. Gangi; Hagar M. Kenawy; Robert M. Stefani; Neeraj Sakhrani; Aaron M. Stoker; James L. Cook; Nadeen O. Chahine; Gerard A. Ateshian; Clark T. Hung)