NOVAJoint Research Project

Building a living knee replacement

ARPA-H Awards Columbia Researchers Nearly $39M to Develop a Living Knee Replacement

Columbia biomedical engineers are collaborating with orthopedic surgeons to build a living replacement knee to be tested in clinical trials within five years.


Graphic of knee bones surrounded by blue and purple light

Credit: ARPA-H

A team of researchers from Columbia University Irving Medical Center (CUIMC) and Columbia Engineering has been awarded up to a $38.95 million contract from the Advanced Research Projects Agency for Health (ARPA-H) on Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO) to build a living knee replacement from biomaterials and human stem cells, including a patient’s own cells. ARPA-H is a federal funding agency that funds transformative biomedical and health research breakthroughs, rapidly translating research from the lab to applications in the marketplace. The NOVAJoint research team is developing a regenerative knee implant to restore full joint function to patients severely impacted by osteoarthritis (OA).  

Learn more about our team, research updates, health equity goals, commercialization plans, and community engagement through the provided links.

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