Engineering Regenerative Strategies for Musculoskeletal Tissues

Project Funding: NIH R41AG050021, AOSSM Young Investigator Award

Computer generated model of an artificial spinal disc scaffold

Engineering regenerative strategies for musculoskeletal repair has specific biomechanical, cellular, molecular and nutrient supply demands. The degree of degeneration also impacts the therapeutic potential of cell based repair. Consequently, conditions for achieving clinical efficacy with cell-based repair must be optimized. We are evaluating and optimizing the biomechanical responses to stem cell based repair, anti-inflammatory and MMP inhibition therapies. We are also developing novel 3D printed scaffolds with optimized functional biomechanical properties for load bearing applications.