Huang Lab


2022 Publications

Axin2-lineage cells contribute to neonatal tendon regeneration
Walia B, Li TM, Crosio G, Montero AM, Huang AH
Connective Tissue Research, 2022


2021 Publications

Reparative and Maladaptive Inflammation in Tendon Healing
Arvind V, Huang AH.
Frontiers in Bioengineering and Biotechnology, 2021, 9:719047.


Transcriptional Profiling of mESC-derived Tendon and Fibrocartilage Cell Fate Switch
Kaji DA, Montero AM, Patel R, Huang AH.
Nature Communications, 2021, 12(1):4208.


ScxLin Cells Directly Form a Subset of Chondrocytes in Temporomandibular Joint that are Sharply Increased in Dmp1-null Mice
Ma C, Jing Y, Li H, Wang K, Wang Z, Xu C, Sun X, Kaji D, Han X, Huang A, Feng J.
Bone, 2021, 142:115687.


Macrophage Depletion Impairs Neonatal Tendon Regeneration
Howell KL, Kaji DA, Li TM, Montero A, Yeoh K, Nasser P, Huang AH.
FASEB Journal, 2021, 35(6):e21618.


Innate and adaptive immune system cells implicated in tendon healing and disease
Crosio G, Huang AH
Cells and Materials, 2021, 43: 39-52

2020 Publications

Loss of Smad4 in Scleraxis Cell Lineage Results in Postnatal Joint Contracture
Schlesinger SY, Seo S, Pryce BA, Tufa SF, Keene DR, Huang AH, Schweitzer R.
Developmental Biology, 2021 470:108-120 (Epub Nov 25 2020).


Ten Simple Rules for Women Principal Investigators During a Pandemic
Kreeger PK, Brock A, Gibbs HC, Grande-Allen KJ, Huang AH, Masters KS, Rangamani P, Reagan MR, Servoss SL.
PLoS Computational Biology, 2020, 16(10:e1008370.


TGFβ Signaling Is Required for Tenocyte Recruitment and Functional Neonatal Tendon Regeneration
Kaji DA, Howell KL, Balic Z, Hubmacher D, Huang AH.
elife, 2020, 9:e51779.


Cell Lineage Tracing and Functional Assessment of Supraspinatus Tendon Healing in an Acute Repair Murine Model
Moser HL, Abraham AC, Howell K, Laudier D, Zumstein MA, Galatz LM, Huang AH.
Journal of Orthopaedic Research, 2021, 39(8):1789-1799 (Epub Jun 15 2020).

2019 Publications

Neonatal Annulus Fibrosus Regeneration Occurs via Recruitment and Proliferation of Scleraxis-lineage Cells
Torre OM, Mroz V, Martinez AR, Huang AH*, Iatridis JC*.
NPJ Regenerative Medicine, 2019, 4(1):23.
*co-corresponding authors


Cellular plasticity in musculoskeletal development, regeneration, and disease
Kaji DA, Tan Z, Johnson GL, Huang W, Vasquez K, Lehoczky JA, Levi B, Cheah KSE, Huang AH.
Journal of Orthopaedic Research, 2020, 38(4):708-718 (Epub Nov 25 2019)
Invited review


Requirement for Scleraxis in the recruitment of mesenchymal progenitors during embryonic tendon elongation
Huang AH*, Watson SS, Wang L, Baker BM, Akiyama H, Brigande JV, Schweitzer R*.
Development, 2019, Epub (Oct 4)
*co-corresponding authors

2018 Publications

Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair
Walia B and Huang AH.
Journal of Orthopaedic Research, 2018, Epub (Oct 1)
Invited Review


Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies
Torre OM, Mroz V, Bartelstein MK, Huang AH*, Iatridis JC*.
Annals of the New York Academy of Sciences, 2018, Epub (Sep 14)
Invited Review
*co-corresponding authors

Genetic lineage tracing of targeted cell populations during enthesis healing
Moser HL, Doe AP, Meier K, Garnier S, Laudier D, Akiyama H, Zumstein MA, Galatz LM, Huang AH.
Journal of Orthopaedic Research, 2018, 36(12):3275-3284.


Biologics and stem-cell based therapies for rotator cuff repair
Bianco S, Moser HL, Galatz LM, Huang AH.
Annals of the New York Academy of Sciences, 2018, Epub (Jul 15).
Invited Review


Chondrocyte and mesenchymal stem cell derived engineered cartilage exhibits differential sensitivity to pro-inflammatory cytokines
Mohanraj B, Huang AH, Yeger-McKeever MJ, Schmidt MJ, Dodge GR, Mauck RL.
Journal of Orthopaedic Research, 2018, 36(11):2901-2910.


Donor-to-donor variability in functional chondrogenesis by human mesenchymal stem cells in hyaluronic acid hydrogels
Steinberg DR, Kim M, Erickson IE, Huang AH, Garrity S, Mauck RL.
Tissue Engineering: Part A, 2018, 21-22:1693-1703.


Neonatal mouse intervertebral discs heal with restored function following herniation injury
Torre OM, Das R, Berenblum RE, Huang AH*, Iatridis JC*.
FASEB Journal, 2018, Epub ahead of print (March 2018)
*co-corresponding authors

2017 Publications

Optimizing a 3D model system for molecular manipulation of tenogenesis
Chun C, Pryce B, Tufa SF, Keene DR, Huang AH.
Connective Tissue Research, 2017, 59(4):295-308.


Mechanobiology of Limb Musculoskeletal Development
Arvind V and Huang AH.
Annals of the New York Academy of Sciences, 2017, 1409(1):18-32.
Invited Review


Coordinated Development of the Limb Musculoskeletal System: Tendon and Muscle Patterning and Integration with the Skeleton
Huang AH.
Developmental Biology, 2017, 429(2):420-428.
Invited Review, Special Issue “Forming and Shaping the Field of Limb Development: A Tribute to Dr. John Saunders,” Guest Editor: Dr. Lee Niswander.


Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing
Howell K, Chien C, Bell R, Laudier D, Tufa SF, Keene DR, Andarawis-Puri N, Huang AH.
Scientific Reports, 2017, 7:45238.

2015 Publications

Musculoskeletal Integration at the Wrist Underlies Modular Development of Limb Tendons
Huang AH, Riordan TJ, Pryce B, Weibel JL, Watson SS, Long F, Lefebvre V, Harfe BD, Stadler HS, Akiyama H, Tufa SF, Keene DR, Schweitzer R.
Development, 2015, 142(14):2431-41.
Featured paper and Cover Art


Molecular Regulation of Tendon Cell Fate During Development
Huang AH*, Lu HH, Schweitzer R.*
Journal of Orthopaedic Research, 2015, 33(6):800-12.
* co-corresponding authors

2013 Publications

Re-positioning forelimb superficialis muscles: tendon attachment and muscle activity enable active relocation of functional myofibers
Huang AH, Riordan TJ, Wang L, Eyal S, Zelzer E, Brigande JV, Schweitzer R.
Developmental Cell, 2013, 26(5): 544-51.